SSP kits for determination of KIR genotypes and their HLA ligands
Natural killer cells (NK) and some T lymphocytes have killer-cell immunoglobulin like receptors (KIRs) on their cell surface. The genetic region of the KIR receptors is characterized by a high variability. Defined HLA class I molecules could be identified as ligands for single KIR receptors.
In bone marrow transplantations, a certain disparity of KIR/HLA can influence the outcome of the transplantation. Furthermore, there are associations between particular KIR Genotypes and autoimmune diseases (e.g psoriasis) and a slower progression of an AIDS disease.
The KIR TYPE kit allows genotyping of 14 KIR Genes plus 2 Pseudogenes.
The Epitop-TYPE kit recognizes the alleles with the HLA specificities HLA-Cw Asn80,, HLA-Cw Lys80, HLA-B Bw4Threo, HLA-B Bw4Iso and HLA-A Bw4.